C43H55N4O10P Uridine, 5′ -O- [bis(4-methoxyphenyl)phenylmethyl]-2′ -O-(2-methox yethyl)- 5-methyl-, 3′ – [2-cyanoethyl N,N-bis(1- methylethyl)phosphor amidite] (ACI)

Taarifa za Msingi:

Tutumie barua pepe

Maelezo ya Bidhaa

Lebo za Bidhaa

Maelezo ya Dawa

Nambari ya Usajili ya CAS

163878-63-5

H302

Sifa Muhimu za Kimwili	Thamani	Hali
Uzito wa Masi	818.89	-
pKa (Iliyotabiriwa)	9.55±0.10	Halijoto ya Asidi Zaidi: 25 °C

Majina Mengine na Vitambulisho

TABASAMU za Kikanuni

N#CCCOP(OC1C(OC(N2C=C(C(=O)NC2=O)C)C1OCCOC)COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5= CC=C(OC)C=C5)N(C(C)C)C(C)C

Isomeric TABASAMU

C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCOC)[C@@ H](O1)N2C(=O)NC(=O)C(C)=C2)(C3=CC=C(OC)C=C3)(C4=CC =C(OC)C=C4)C5= CC=CC=C5

InChI

InChI= 1S/C43H55N4O10P/c1-29(2)47(30(3)4)58(55-24-12-23-44)57-38-37(56-41(39(38)53-26- 25-50-6)46-27-31(5)40(48)45-42(46)49)2 8-54-43(32-13-10-9-11-14-32,33-15) -19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,27,29-30,37-39 ,41H,12,24-26,28H2, 1-8H3,(H,45,48,49)/t37-,38-,39-,41-,58?/m1/s1

Ufunguo wa InChI

YFRRKZDUDXHJNC-KZQAAKLLSA-N

17 Majina Mengine ya Dawa hii

Uridine, 5′-O- [bis(4-methoxyphenyl)phenylmethyl]-2′ -O-(2-methoxyethyl)- 5-methyl-, 3′ - [2-cyanoethyl bis(1-methylethyl)phosphor

amidite] (9CI); 10: PN: US20030212017 UKURASA: 18 walidai RNA; 11: PN: US20030211606 UKURASA: 18 walidai RNA; 13: PN: US20040

005569 UKURASA: 21 walidai RNA; 13: PN: US20040006030 UKURASA: 22 walidai RNA; 13: PN: US20040014048 UKURASA: 19 walidai RNA; 13: PN: US20040014049 UKURASA: 19 walidai RNA; 14: PN: US20030198965 UKURASA: 19 walidai RNA; 14: PN: US20040005565 UKURASA: 17- 22 alidai RNA; 14: PN: US20040005570 UKURASA: 19 walidai RNA; 14: PN: US20040014047 UKURASA: 19 walidai RNA; 14: PN: US20040

014699 UKURASA: 19 walidai RNA; 15: PN: US20040014050 UKURASA: 19 walidai RNA; 15: PN: US20040014051 UKURASA: 21 walidai RNA; 15:

PN: WO03106645 UKURASA: 69 walidai RNA; 16: PN: US20040006029 UKURASA: 22 walidai RNA; 87: PN: US20040005707 UKURASA: 19 walidai RNA

Spectra ya Majaribio

Spectra inapatikana
1 H NMR
13 C NMR
Hetero NMR

Mali Zilizotabiriwa

Mali zinazopatikana
Kibiolojia
Kemikali
Lipinski
Kuhusiana na Muundo

Kibiolojia

Mali	Thamani	Hali	Chanzo
Kipengele cha Mkusanyiko wa Kibiolojia	348	pH 1; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	2810	pH 2; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	21100	pH 3; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	63100	pH 4; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	78800	pH 5; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	80800	pH 6; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	80800	pH 7; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	78800	pH 8; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	63400	pH 9; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	21800	pH 10; Joto: 25 °C	(1) ACD

Kemikali

Mali	Thamani	Hali	Chanzo
Koc	487	pH 1; Joto: 25 °C	(1) ACD
Koc	3940	pH 2; Joto: 25 °C	(1) ACD
Koc	29600	pH 3; Joto: 25 °C	(1) ACD
Koc	88400	pH 4; Joto: 25 °C	(1) ACD

Mali	Thamani	Hali	Chanzo
Koc	1.10 x 105	pH 5; Joto: 25 °C	(1) ACD
Koc	1.13 x 105	pH 6; Joto: 25 °C	(1) ACD
Koc	1.13 x 105	pH 7; Joto: 25 °C	(1) ACD
Koc	1.10 x 105	pH 8; Joto: 25 °C	(1) ACD
Koc	88800	pH 9; Joto: 25 °C	(1) ACD
Koc	30600	pH 10; Joto: 25 °C	(1) ACD
logD	4.39	pH 1; Joto: 25 °C	(1) ACD
logD	5.30	pH 2; Joto: 25 °C	(1) ACD
logD	6.18	pH 3; Joto: 25 °C	(1) ACD
logD	6.65	pH 4; Joto: 25 °C	(1) ACD
logD	6.75	pH 5; Joto: 25 °C	(1) ACD
logD	6.76	pH 6; Joto: 25 °C	(1) ACD
logD	6.76	pH 7; Joto: 25 °C	(1) ACD
logD	6.75	pH 8; Joto: 25 °C	(1) ACD
logD	6.65	pH 9; Joto: 25 °C	(1) ACD
logD	6.19	pH 10; Joto: 25 °C	(1) ACD
logP	6.761±0.669	Joto: 25 °C	(1) ACD
Umumunyifu wa Ndani wa Misa	2.0 x 10-4 g/L	Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	0.046 g/L	pH 1; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	5.7 x 10-3 g/L	pH 2; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	7.6 x 10-4 g/L	pH 3; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	2.5 x 10-4 g/L	pH 4; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	2.0 x 10-4 g/L	pH 5; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	2.0 x 10-4 g/L	pH 6; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	2.0 x 10-4 g/L	pH 7; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	2.0 x 10-4 g/L	pH 8; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	2.5 x 10-4 g/L	pH 9; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	7.4 x 10-4 g/L	pH 10; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	2.0 x 10-4 g/L	Maji yasiyo na buffered pH 7.00; Joto: 25 °C	(1) ACD
Umumunyifu wa Ndani wa Molar	2.4 x 10-7 mol/L	Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	5.6 x 10-5 mol/L	pH 1; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	7.0 x 10-6 mol/L	pH 2; Joto: 25 °C	(1) ACD

Mali	Thamani	Hali	Chanzo
Umumunyifu wa Molar	9.3 x 10-7 mol/L	pH 3; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	3.1 x 10-7 mol/L	pH 4; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	2.5 x 10-7 mol/L	pH 5; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	2.4 x 10-7 mol/L	pH 6; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	2.4 x 10-7 mol/L	pH 7; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	2.5 x 10-7 mol/L	pH 8; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	3.1 x 10-7 mol/L	pH 9; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	9.0 x 10-7 mol/L	pH 10; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	2.4 x 10-7 mol/L	Maji yasiyo na buffered pH 7.00; Joto: 25 °C	(1) ACD
Uzito wa Masi	818.89
pKa	9.55±0.10	Halijoto ya Asidi Zaidi: 25 °C	(1) ACD
pKa	3.45±0.70	Joto la Msingi Zaidi: 25 °C	(1) ACD

Lipinski

Mali	Thamani	Hali	Chanzo
Vifungo vinavyoweza kuzungushwa kwa Uhuru	21		(1) ACD
H Wakubali	14		(1) ACD
H Wafadhili	1		(1) ACD
H Jumla ya Mfadhili/Mpokeaji	15		(1) ACD
logP	6.761±0.669	Joto: 25 °C	(1) ACD
Uzito wa Masi	818.89