C47H60N7O10P Guanosine, 5′ -O- [bis(4-methoxyphenyl)phenylmethyl]-2′ -O-(2- methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′ – [2-cyanoethyl N ,N-bis (1-methylethyl)phosphoramidite] (ACI)

Taarifa za Msingi:

Tutumie barua pepe

Maelezo ya Bidhaa

Lebo za Bidhaa

Maelezo ya Dawa

Nambari ya Usajili ya CAS

251647-55-9

H302

Sifa Muhimu za Kimwili	Thamani	Hali
Uzito wa Masi	914.00	-
pKa (Iliyotabiriwa)	9.16±0.20	Halijoto ya Asidi Zaidi: 25 °C

Majina Mengine na Vitambulisho

TABASAMU za Kikanuni

N#CCCOP(OC1C(OC(N2C= NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OCCOC)COC(C=4C=CC=CC4)(C5=CC =C(OC)C=C5)C6=CC=C(OC)C=C6) N(C(C)C)C(C)C

Isomeric TABASAMU

C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OCCOC)[C@@ H](O1)N2C3=C(N=C2)C(=O)N=C(NC(C(C)C)=O)N3)(C4=CC=C (OC)C=C4)(C5) =CC=C(OC)C=C5)C6=CC=CC=C6

InChI

InChI= 1S/C47H60N7O10P/c1-30(2)43(55)51-46-50-42-39(44(56)52-46)49-29-53(42)45-41(60-27- 26-57-7)40(64-65(62-25-13-24-48)54( 31(3)4)32(5)6)38(63-45)28-61-47(33- 14-11-10-12-15-33,34-16-20-36(58-8)21-17-34)35-18-22-37(59-9)23-19-35/h10- 12,14-23,29-32,38 ,40-41,45H,13,25-28H2,1-9H3,(H2,50,51,52,55,56)/t38-,40-,41- ,45-,65?/m1/s1

Ufunguo wa InChI

LADCDGNEBIQAAU-SBCRAQIVSA-N

17 Majina Mengine ya Dawa hii

Guanosine, 5′-O- [bis(4-methoxyphenyl)phenylmethyl]-2′ -O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 3′ - [2-cyanoethyl bis(1- methylethyl)phosphoramidite] (9CI); 17: PN: US20030212017 UKURASA: Mlolongo 20 unaodaiwa; 18: PN: US20030211606 UKURASA: 20

mlolongo unaodaiwa; 19: PN: US20040005569 UKURASA: 22 mlolongo unaodaiwa; 21: PN: US20040006030 UKURASA: 23 mlolongo unaodaiwa; 21: PN: US20040014047 UKURASA: 21 mlolongo unaodaiwa; 21: PN: US20040014049 UKURASA: 21 mlolongo unaodaiwa; 22: PN: US20030198965 PAG

E: mlolongo 20 unaodaiwa; 22: PN: US20040005570 UKURASA: 21 mlolongo unaodaiwa; 22: PN: US20040014048 UKURASA: 21 mlolongo unaodaiwa;

22: PN: US20040014050 UKURASA: 21 mlolongo unaodaiwa; 23: PN: US20040005565 UKURASA: 17- 22 mlolongo unaodaiwa; 23: PN: US20040

014051 UKURASA: 23 mlolongo unaodaiwa; 24: PN: US20040014699 UKURASA: 21 mlolongo unaodaiwa; 25: PN: US20040006029 UKURASA: 23 mlolongo unaodaiwa; 25: PN: WO03106645 UKURASA: 73 mlolongo unaodaiwa; 96: PN: US20040005707 UKURASA: 21 mlolongo unaodaiwa

Spectra ya Majaribio

Spectra inapatikana
13 C NMR
Hetero NMR

Mali Zilizotabiriwa

Mali zinazopatikana
Kibiolojia
Kemikali
Lipinski
Kuhusiana na Muundo

Kibiolojia

Mali	Thamani	Hali	Chanzo
Kipengele cha Mkusanyiko wa Kibiolojia	121	pH 1; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	2580	pH 2; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	23500	pH 3; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	71800	pH 4; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	89800	pH 5; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	92100	pH 6; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	91300	pH 7; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	82500	pH 8; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	42200	pH 9; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	7860	pH 10; Joto: 25 °C	(1) ACD

Kemikali

Mali	Thamani	Hali	Chanzo
Koc	164	pH 1; Joto: 25 °C	(1) ACD
Koc	3480	pH 2; Joto: 25 °C	(1) ACD
Koc	31700	pH 3; Joto: 25 °C	(1) ACD
Koc	96900	pH 4; Joto: 25 °C	(1) ACD
Koc	1.21 x 105	pH 5; Joto: 25 °C	(1) ACD

Mali	Thamani	Hali	Chanzo
Koc	1.24 x 105	pH 6; Joto: 25 °C	(1) ACD
Koc	1.23 x 105	pH 7; Joto: 25 °C	(1) ACD
Koc	1.11 x 105	pH 8; Joto: 25 °C	(1) ACD
Koc	56900	pH 9; Joto: 25 °C	(1) ACD
Koc	10600	pH 10; Joto: 25 °C	(1) ACD
logD	3.95	pH 1; Joto: 25 °C	(1) ACD
logD	5.28	pH 2; Joto: 25 °C	(1) ACD
logD	6.24	pH 3; Joto: 25 °C	(1) ACD
logD	6.73	pH 4; Joto: 25 °C	(1) ACD
logD	6.82	pH 5; Joto: 25 °C	(1) ACD
logD	6.83	pH 6; Joto: 25 °C	(1) ACD
logD	6.83	pH 7; Joto: 25 °C	(1) ACD
logD	6.79	pH 8; Joto: 25 °C	(1) ACD
logD	6.50	pH 9; Joto: 25 °C	(1) ACD
logD	5.77	pH 10; Joto: 25 °C	(1) ACD
logP	6.837±0.764	Joto: 25 °C	(1) ACD
Umumunyifu wa Ndani wa Misa	4.4 x 10-4 g/L	Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	0.34 g/L	pH 1; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	0.016 g/L	pH 2; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	1.7 x 10-3 g/L	pH 3; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	5.7 x 10-4 g/L	pH 4; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	4.6 x 10-4 g/L	pH 5; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	4.4 x 10-4 g/L	pH 6; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	4.5 x 10-4 g/L	pH 7; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	4.9 x 10-4 g/L	pH 8; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	1.0 x 10-3 g/L	pH 9; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	5.2 x 10-3 g/L	pH 10; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	4.5 x 10-4 g/L	Maji yasio na buffered pH 6.99; Joto: 25 °C	(1) ACD
Umumunyifu wa Ndani wa Molar	4.8 x 10-7 mol/L	Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	3.7 x 10-4 mol/L	pH 1; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.7 x 10-5 mol/L	pH 2; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.9 x 10-6 mol/L	pH 3; Joto: 25 °C	(1) ACD

Mali	Thamani	Hali	Chanzo
Umumunyifu wa Molar	6.2 x 10-7 mol/L	pH 4; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	5.0 x 10-7 mol/L	pH 5; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	4.8 x 10-7 mol/L	pH 6; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	4.9 x 10-7 mol/L	pH 7; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	5.4 x 10-7 mol/L	pH 8; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.1 x 10-6 mol/L	pH 9; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	5.7 x 10-6 mol/L	pH 10; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	4.9 x 10-7 mol/L	Maji yasio na buffered pH 6.99; Joto: 25 °C	(1) ACD
Uzito wa Masi	914.00
pKa	9.16±0.20	Halijoto ya Asidi Zaidi: 25 °C	(1) ACD
pKa	3.45±0.70	Joto la Msingi Zaidi: 25 °C	(1) ACD

Lipinski

Mali	Thamani	Hali	Chanzo
Vifungo vinavyoweza kuzungushwa kwa Uhuru	22		(1) ACD
H Wakubali	17		(1) ACD
H Wafadhili	2		(1) ACD
H Jumla ya Mfadhili/Mpokeaji	19		(1) ACD
logP	6.837±0.764	Joto: 25 °C	(1) ACD
Uzito wa Masi	914.00