C45H56N7O9P Guanosine, 5′ -O- [bis(4-methoxyphenyl)phenylmethyl]-2′ -O-methyl- N-(2-methyl-1-oxopropyl)-, 3′ – [2-cyanoethyl N,N-bis (1-methylethyl) phosphoramidite] (ACI)

Taarifa za Msingi:

Tutumie barua pepe

Maelezo ya Bidhaa

Lebo za Bidhaa

Maelezo ya Dawa

Nambari ya Usajili ya CAS

150780-67-9

H303

Sifa Muhimu za Kimwili	Thamani	Hali
Uzito wa Masi	869.94	-
pKa (Iliyotabiriwa)	9.16±0.20	Halijoto ya Asidi Zaidi: 25 °C

Majina Mengine na Vitambulisho

N#CCCOP(OC1C(OC(N2C= NC=3C(=O)N=C(NC(=O)C(C)C)NC32)C1OC)COC(C=4C=CC=CC4)(C5=CC =C(OC)C=C5)C6=CC=C(OC)C=C6)N(C(C)C)C(C)C

Isomeric TABASAMU

C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@@ H](O1)N2C3=C(N=C2)C(=O)N=C(NC(C(C)C)=O)N3)(C4=CC=C(OC) C=C4)(C5=CC=C(OC)C=C5)C6=CC=CC=C6

InChI

InChI= 1S/C45H56N7O9P/c1-28(2)41(53)49-44-48-40-37(42(54)50-44)47-27-51(40)43-39(57-9) 38(61-62(59-25-13-24-)

46)52(29(3)4)30(5)6)36(60-43)26-58-45(31-14-11-10-12-15-31,32-1 6-20-34(55-7)21-17-32)33-18-22-35(56-8)23-19-33/h10-12,14-23,27 -30,36,38-39,43H,13,25-26H2,1-9H3,(H2,48,49,50,53,54)/t36-,38-,39-,43-,62?/ m1/s1

Ufunguo wa InChI

IRRDHRZUOZNWDJ-MLLDKZSOSA-N

1 Jina Lingine la Dawa hii

Guanosine, 5′-O- [bis(4-methoxyphenyl)phenylmethyl]-2′ -O-methyl-N-(2-methyl-1-oxopropyl)-, 3′ - [2-cyanoethyl bis(1-methylethyl) phosphoramidite] (9CI)

Spectra ya Majaribio

Spectra inapatikana
13 C NMR
Hetero NMR

Mali Zilizotabiriwa

Mali zinazopatikana
Kibiolojia
Kemikali
Lipinski
Kuhusiana na Muundo

Kibiolojia

Mali	Thamani	Hali	Chanzo
Kipengele cha Mkusanyiko wa Kibiolojia	183	pH 1; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	3890	pH 2; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	35500	pH 3; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	1.08 x 105	pH 4; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	1.36 x 105	pH 5; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	1.39 x 105	pH 6; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	1.38 x 105	pH 7; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	1.24 x 105	pH 8; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	63600	pH 9; Joto: 25 °C	(1) ACD
Kipengele cha Mkusanyiko wa Kibiolojia	11900	pH 10; Joto: 25 °C	(1) ACD

Kemikali

Mali	Thamani	Hali	Chanzo
Koc	220	pH 1; Joto: 25 °C	(1) ACD
Koc	4680	pH 2; Joto: 25 °C	(1) ACD
Koc	42600	pH 3; Joto: 25 °C	(1) ACD
Koc	1.30 x 105	pH 4; Joto: 25 °C	(1) ACD
Koc	1.63 x 105	pH 5; Joto: 25 °C	(1) ACD
Koc	1.67 x 105	pH 6; Joto: 25 °C	(1) ACD
Koc	1.65 x 105	pH 7; Joto: 25 °C	(1) ACD
Koc	1.49 x 105	pH 8; Joto: 25 °C	(1) ACD

Mali	Thamani	Hali	Chanzo
Koc	76400	pH 9; Joto: 25 °C	(1) ACD
Koc	14200	pH 10; Joto: 25 °C	(1) ACD
logD	4.19	pH 1; Joto: 25 °C	(1) ACD
logD	5.52	pH 2; Joto: 25 °C	(1) ACD
logD	6.48	pH 3; Joto: 25 °C	(1) ACD
logD	6.96	pH 4; Joto: 25 °C	(1) ACD
logD	7.06	pH 5; Joto: 25 °C	(1) ACD
logD	7.07	pH 6; Joto: 25 °C	(1) ACD
logD	7.07	pH 7; Joto: 25 °C	(1) ACD
logD	7.02	pH 8; Joto: 25 °C	(1) ACD
logD	6.73	pH 9; Joto: 25 °C	(1) ACD
logD	6.00	pH 10; Joto: 25 °C	(1) ACD
logP	7.072±0.721	Joto: 25 °C	(1) ACD
Umumunyifu wa Ndani wa Misa	1.2 x 10-4 g/L	Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	0.096 g/L	pH 1; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	4.3 x 10-3 g/L	pH 2; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	4.8 x 10-4 g/L	pH 3; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	1.6 x 10-4 g/L	pH 4; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	1.2 x 10-4 g/L	pH 5; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	1.2 x 10-4 g/L	pH 6; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	1.2 x 10-4 g/L	pH 7; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	1.4 x 10-4 g/L	pH 8; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	2.7 x 10-4 g/L	pH 9; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	1.4 x 10-3 g/L	pH 10; Joto: 25 °C	(1) ACD
Umumunyifu wa Misa	1.2 x 10-4 g/L	Maji yasiyo na buffered pH 7.00; Joto: 25 °C	(1) ACD
Umumunyifu wa Ndani wa Molar	1.4 x 10-7 mol/L	Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.1 x 10-4 mol/L	pH 1; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	5.0 x 10-6 mol/L	pH 2; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	5.5 x 10-7 mol/L	pH 3; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.8 x 10-7 mol/L	pH 4; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.4 x 10-7 mol/L	pH 5; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.4 x 10-7 mol/L	pH 6; Joto: 25 °C	(1) ACD

Mali	Thamani	Hali	Chanzo
Umumunyifu wa Molar	1.4 x 10-7 mol/L	pH 7; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.6 x 10-7 mol/L	pH 8; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	3.1 x 10-7 mol/L	pH 9; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.6 x 10-6 mol/L	pH 10; Joto: 25 °C	(1) ACD
Umumunyifu wa Molar	1.4 x 10-7 mol/L	Maji yasiyo na buffered pH 7.00; Joto: 25 °C	(1) ACD
Uzito wa Masi	869.94
pKa	9.16±0.20	Halijoto ya Asidi Zaidi: 25 °C	(1) ACD
pKa	3.45±0.70	Joto la Msingi Zaidi: 25 °C	(1) ACD

Lipinski

Mali	Thamani	Hali	Chanzo
Vifungo vinavyoweza kuzungushwa kwa Uhuru	19		(1) ACD
H Wakubali	16		(1) ACD
H Wafadhili	2		(1) ACD
H Jumla ya Mfadhili/Mpokeaji	18		(1) ACD
logP	7.072±0.721	Joto: 25 °C	(1) ACD
Uzito wa Masi	869.94